Matrix Metalloproteinase-12 (MMP-12)

Matrix Metalloproteinase-12 (MMP-12), also known as Macrophage metalloesterase, is responsible for the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin. Found in alveolar macrophages but not in peripheral blood monocytes, MMP-12 is induced by exposure to bacterial lipopolysaccharides (LPS). It is inhibited by dexamethasone and thought to be integral to wound healing.

Swiss-Prot Accession Number: P39900


 
Product Associations Product Associations

This analyte is not currently part of Myriad RBM's testing menu.

 
 
Therapy Indications
Cytokines/Chemokines
 
Myriad RBM Publications Publications
Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome. (2019) Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Pare G Circulation
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