Interferon alpha (IFN-alpha)
Interferon alpha (IFN alpha, IFNa) is a member of the type I interferon family. Dendritic cells are a major source of IFN alpha and the protein is involved in the innate immune response to viral infection, but also cell differentiation and anti-tumor responses. Recombinant IFN used as antiviral therapy for Hepatitis B, Hepatitis C, but also against cancers like Melanoma and T cell Lymphoma. IFN alpha shares a receptor with IFN beta, although with different affinities. The two proteins have overlapping as well as distinct gene expression patterns. Research has linked IFN alpha to autoimmune diseases.
Swiss-Prot Accession Number: P01563
Transcutaneous auricular vagus nerve stimulation reduces pain and fatigue in patients with systemic lupus erythematosus: a randomised, double-blind, sham-controlled pilot trial (2020) Aranow C, Atish-Fregoso Y, Lesser M, Mackay M, Anderson E, Chavan S, Zanos TP, Datta-Chaundhuri T, Bouton C, Tracey KJ, Diamond B Annals of the rheumatic diseases
Dietary Buglossoides Arvensis Oil Increases Circulating n-3 Ployunsaturated Fatty Acids in a Dose Dependent Manner and Enhances Lipopolysaccharide-Stimulated Whole Blood Interleukin-10-A Randomized Placebo-Controlled Trial. (2017) Lefort N, LeBlanc R, Surette M Nutrients
Self-reactive IgE exacerbates interferon responses associated with autoimmunity (2015) Henault J, Riggs JM, Karnell JL, Liarski VM, Li J, Shirinian L, Xu L, Casey KA, Smith MA, Khatry DB, Izhak L, Clarke L, Herbst R, Ettinger R, Petri M, Clark MR, Mustelin T, Kolbeck R, Sanjuan MA Nat Immunol.