Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) is one of four known members of the TIMP family which functions to regulate MMP activation. MMPs participate in accelerated breakdown of connective tissue matrix. They are associated with a number of diseases such as arthritis, atherosclerosis, tissue ulcerations, and tumor cell invasion and metastasis. TIMP-2 has been shown to interact with MMP14 and MMP2. TIMP-2 also has functions that are independent of MMP inhibition. High levels of TIMP-2 correlate with survival in human breast cancer.
Early Plasma Matrix Metalloproteinase Profiles: A Novel Pathway in Pediatric Acute Respiratory Distress Syndrom (2018) Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A American Journal of Respiratory and Critical Care Medicine
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. (2017) Castellano JM, Mosher KI, Abbey RJ, McBride AA, James ML, Berdnik D, Shen JC, Zou B, Xie XS, Tingle M, Hinkson IV, Angst MS, Wyss-Coray T Nature
Molecular indicators of non-sentinel node status in breast cancer determined in preoperative biopsies by multiplexed sandwich immunoassays (2011) Sauer G, Schneiderhan-Marra N, Muche R, Koretz K, Kazmaier C, Kreienberg R, Joos T, Deissler H J Cancer Res Clin Oncol. 2011 Apr 24. [Epub ahead of print]
Matrix metalloproteinases during and outside of migraine attacks without aura. (2009) Ashina M, Tvedskov JF, Lipka K, Bilello J, Penkowa M, Olesen J Cephalalgia 30: 303-310.