Tissue Inhibitor of Metalloproteinases 2 (TIMP-2)
Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) is one of four known members of the TIMP family which functions to regulate MMP activation. MMPs participate in accelerated breakdown of connective tissue matrix. They are associated with a number of diseases such as arthritis, atherosclerosis, tissue ulcerations, and tumor cell invasion and metastasis. TIMP-2 has been shown to interact with MMP14 and MMP2. TIMP-2 also has functions that are independent of MMP inhibition. High levels of TIMP-2 correlate with survival in human breast cancer.
Swiss-Prot Accession Number: P16035
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