Resistin

Resistin (Resistin)

Resistin is a hormone secreted by adipose tissue. The length of the resistin pre-peptide in rat is 114 aa; the molecular weight is ~12.5 kDa. Among the hormones synthesized and released from adipose tissue (adiponectin, angiotensin, estradiol, IL-6, leptin, PAI-1, TNF-a, and resistin), resistin is an adipocytokine whose physiologic role has been the subject of much controversy with regards to its involvement with obesity and type II diabetes mellitus. Resistin was first discovered in 2001 and was originally found to be produced and released from adipose tissue to serve endocrine functions likely involved in insulin resistance. This idea primarily stems from studies demonstrating that serum resistin levels increase with obesity in several model systems. Since these observations, further research has linked resistin to other physiological systems such as inflammation and energy homeostasis.

Swiss-Prot Accession Number: Q9HD89

Publications

Molecular Epidemiology of Inflammation Link with Type 2 Diabetes and Coronary Heart Disease (2020) Ligthart S Erasmus University Rotterdam

A randomized, controlled trial on the effects of almonds on lipoprotein response to a higher carbohydrate, lower fat diet in men and women with abdominal adiposity (2019) Williams PT, Bergeron N, Chiu S, Krauss RM Lipids in Health and Disease

Blood-based protein mediators of senility with replications across biofluids (2019) Royall DR, Palmer RF, The Alzheimer's Disease Neuroimaging Initiative Brain Communications

Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One

Relation of antioxidant capacity of diet and markers of oxidative status with C-reactive protein and adipocytokines: a prospective study. (2017) Stringa N, Brahimaj A, Zaciragic A, Dehghan A, Ikram MA, Hofman A, Muka T, Kiefte-de Jong JC, Franco OH Metab.

Serum proteins mediate depression’s association with dementia (2017) Royall DR, Al-Rubaye S, Bishnoi R, Palmer RF Plos One

Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports

Identifying amyloid pathology–related cerebrospinal fluid biomarkers for Alzheimer's disease in a multicohort study (2015) Leung YY, Toledo JB, Nefedov A, Polikar R, Raghavan N, Xie SX, Farnum M, Schultz T, Baek Y, Deerlin VV, Hu WT, Holtzman DM, Fagan AM, Perrin RJ, Grossman M, Soares HD, Kling MA, Mailman M, Arnold SE, Narayan VA, Lee VMY, Shaw LM, Baker D, Wittenberg GM, Trojanowski JQ, Wang LS Alzheimer's & Dementia

Identification of Subgroups of Schizophrenia Patients with Changes in Either Immune or Growth Factor and Hormonal Pathways (2013) Schwarz E, Van Beveren NJM, Ramsey J, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Guest PC, Bahn S Schizophrenia Bulletin

Blood profiling of proteins and steroids during weight maintenance with manipulation of dietary protein level and glycaemic index (2012) Wang P, Holst C, Astrup A, Bouwman FG, van Otterdijk S, Wodzig WK, Andersen MR, van Baak MA, Rasmussen LG, Martinez JA, Jebb SA, Pfeiffer AF, Kafatos A, Handjieva-Darlenska T, Hlavaty P, Saris WH, Mariman EC Br J Nutr. 2012 Jan;107(1):106-19

A Serum Protein-Based Algorithm for the Detection of Alzheimer Disease (2010) O'Bryant SE, Xiao G, Barber R, Reisch J, Doody R, Fairchild T, Adams P, Waring S, Diaz-Arrastia R; for the Texas Alzheimer's Research Consortium Arch Neurol 67: 1077-1081.

Identification of targeted analyte clusters for studies of schizophrenia. (2010) Cheng TM, Lu YE, Guest PC, Rahmoune H, Harris LW, Wang L, Ma D, Stelzhammer V, Umrania Y, Wayland MT, Lió P, Bahn S Mol Cell Proteomics 9: 510-522.

Plasma Protein Profiling Reveals Protein Clusters Related to BMI and Insulin Levels in Middle-Aged Overweight Subjects (2010) van Dijk SJ, Feskens EJM, Heidema AG, Bos MB, van de Rest O, Geleijnse JM, de Groot LCPGM, Muller M, Afman LA PLoS ONE 12: e14422.

Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment (2010) Hu WT, Chen-Plotkin A, Arnold SE, Grossman M, Clark CM, Shaw LM, Pickering E, Kuhn M, Chen Y, McCluskey L, Elman L, Karlawish J, Hurtig HI, Siderowf A, Lee VM, Soares H, Trojanowski JQ Acta Neuropathol 119: 669-678.