Prostate Specific Antigen (PSA) is a glycoprotein monomer with protease activity. PSA is localized in the cytoplasm of prostatic ductal epithelium and in secretions of the ductal lumina. PSA has been found to be primarily associated with prostate tissue, and elevated serum PSA has been found in patients with prostate cancer, benign prostatic hypertrophy, and inflammatory conditions of other adjacent genitourinary tissues; but not in healthy men, men with nonprostatic carcinoma, healthy women, or women with cancer.
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A Canonical Transforming Growth Factor Beta-Dependent Signaling Pathway is Present in Peripheral Blood Cells of Cancer Patients with Skeletal Metastasis (2013) Kadam S, Cleverly AL, Farmen M, Grondin J, Cox YI, Lahn M J Mol Biomark Diagn 2013, 4:3
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