Platelet-Derived Growth Factor BB (PDGF-BB)

Platelet-derived growth factor (PDGF) is a glycosylated, disulfide-linked dimer that is a potent mitogen for cells of mesenchymal origin. There are 2 polypeptide, A (16 kDa) and B (14 kDa), sharing about 50% sequence identity. They form homo and heterodimers. The expression of each dimer varies by type of cell. The three forms of PDGF have different but overlapping biological activities. The major source of PDGF in human blood is platelets, where PDGF-AA and -AB are stored and released when platelets are activated. A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor. Platelet-Derived Growth factor beta (PDGF-BB) detects the PDGF-BB homodimer, with little cross- reactivity to PDGF-AA and PDGF-AB.

Swiss-Prot Accession Number: P01127

Myriad RBM Publications Publications
Platelet-derived growth factor-BB and white matter hyperintensity burden in APOE4 carriers (2022) Arunima Kapoor, Daniel A Nation Cerebral Circulation - Cognition and Behavior
A phase 1b trial of the CXCR4 inhibitor mavorixafor and nivolumab in advanced renal cell carcinoma patients with no prior response to nivolumab monotherapy (2021) Choueiri TK, Atkins MB, Rose TL, Alter RS, Yawen J, Niland K, Wang Y, Arbeit R, Parasuraman S, Gan L, McDermott DF Investigational New Drugs
Proteomic profiling as a diagnotic biomarker for discriminating between bipolar and unipolar depression (2020) Kittel-Schneider S, Hahn T, Haenisch F,McNeill R, Reif A, Bahn S Frontiers in Psychiatry
Early changes in immune, coagulation, and organ function after clinical and experimental polytrauma (2019) Halbgbauer Repositorium der Universit?t Ulm
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Networks of blood proteins in the neuroimmunology of schizophrenia (2018) Jeffries CD, Perkins DO, Fournier M, Do KQ, Cuenod M, Khadimallah I, Domenici E, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Mathalon DH, McGlashan TH, Seidman LJ, Tsuang M, Walker EF, Woods SW Transl Psychiatry
Complexity of Macrophage Migration Inhibitory Factor (MIF) and Other Angiogenic Biomarkers Profiling in Pulmonary Arterial Hypertension. (2017) Marshall JD, Sauler M, Tonelli A, Rao Y, Bucala R, Lee P, Fares W Pulm Circ.
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports
Allogeneic mesenchymal stem cell infusion for the stabilization of focal segmental glomerulosclerosis (2013) Belingheri M, Lazzari L, Parazzi V, Groppali E, Biagi E, Gaipa G, Giordano R, Rastaldi MP, Croci D, Biondi A, Rebulla P, Edefonti A, Ghio L Biologicals. 2013 Oct 14. pii: S1045-1056(13)00111-5. doi: 10.1016/j.biologicals.2013.09.004