Platelet-Derived Growth Factor (PDGF)

Platelet-derived growth factor (PDGF) is a glycosylated, disulfide-linked dimer that is a potent mitogen for cells of mesenchymal origin. There are 2 polypeptide, A (16 kDa) and B (14 kDa), sharing about 50% sequence identity. They form homo- and heterodimers. The expression of each dimer varies by type of cell. The three forms of PDGF have different but overlapping biological activities. The major source of PDGF in human blood is platelets, where PDGF-AA and -AB are stored and released when platelets are activated. A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor. Platelet-Derived Growth factor beta (PDGF-BB) detects the PDGF-BB homodimer, with little cross-reactivity to PDGF-AA and PDGF-AB.

Swiss-Prot Accession Number: P04085, P01127


 
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This analyte is not currently part of Myriad RBM's testing menu.

 
 
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Myriad RBM Publications Publications
Blood-based protein mediators of senility with replications across biofluids (2019) Royall DR, Palmer RF, The Alzheimer's Disease Neuroimaging Initiative Brain Communications
Von Willebrand factor and ADAMTS13 activity in relation to risk of dementia: a population-based study (2018) Wolters F, Boender J, de Vries P, Sonneveld M, Koudstaal P, de Maat M, Franco O, Ikram M, Leebeek F, Ikram MA Scientific Reports 2018 Apr
Identification of Subgroups of Schizophrenia Patients with Changes in Either Immune or Growth Factor and Hormonal Pathways (2013) Schwarz E, Van Beveren NJM, Ramsey J, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Guest PC, Bahn S Schizophrenia Bulletin
Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment (2010) Hu WT, Chen-Plotkin A, Arnold SE, Grossman M, Clark CM, Shaw LM, Pickering E, Kuhn M, Chen Y, McCluskey L, Elman L, Karlawish J, Hurtig HI, Siderowf A, Lee VM, Soares H, Trojanowski JQ Acta Neuropathol 119: 669-678.