Myeloid Progenitor Inhibitory Factor 1 (MPIF-1; CCL23) is a highly basic protein, highly chemotactic for resting T-cells and monocytes and slightly chemotactic for neutrophils. It is found predominately in lung and liver tissue but also found in bone marrow and placenta. It has been found to inhibit activity of hematopoietic progenitor cells. High levels in adult lung, liver, skeletal muscle, and pancreas. Moderate levels are found in fetal liver, adult bone marrow, and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients.
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Plasma proteomics in CML patients before and after initiation of tyrosine kinase inhibitor therapy reveals induced Th1 immunity and loss of angiogenic stimuli. (2016) Söderlund S, Christiansson L, Persson I, Hjorth-Hansen H, Richter J, Simonsson B, Mustjoki S, Olsson-Strömberg U, Loskog A. Leuk Res