Interleukin-12 Subunit p70

Interleukin-12 Subunit p70 (IL-12p70)

Interleukin-12 p70 (IL-12p70) is the 70 kDa subunit of IL-12. It is produced mainly by B-cells and to a lesser extent by T-cells. The most powerful inducers of IL-12 are bacteria, bacterial products, and parasites. It has been shown to augment natural killer-cell mediated cytotoxicity in a number of conditions, including patients with hairy cell leukemia, and it has been shown to inhibit the growth of a variety of experimental tumors in vivo. IL-12 also has anti-angiogenic effects in vivo, which are in part, mediated by IFN-gamma. IL-12 is potential candidate for the treatment of angiogenesis-dependent malignancies.

Swiss-Prot Accession Number: P29459, P29460

Publications

Association of occupational exposures with ex vivo functional immune response in workers handling carbon nanotubes and nanofibers (2020) Schubauer-Berigan MK, Dahm MM, Toennis CA, Sammons DL, Eye T, Kodali V, Zeidler-Erdely PC, Erdely A Nanotoxicology

Systematic investigation of polyurethane biomaterial surface roughness on human immune responses in vitro (2020) Segan S, Jakobi M, Khokhani P, Klimosch S, Billing F, Schneider M, Martin D, Metzger U, Biesemeier A, Xiong X, Mukherjee A, Steuer H BioMed Research International

Innate Immune Stimulation of Whole Blood Reveals IFN-1 Hyper-Responsiveness in Type 1 Diabetes (2020) Rodrigues KB, Dufort MJ, Llibre A, Speake C, Jubayer Rahman M, Bondet V, Quiel J, Linsley PS, Greenbaum CJ, Duffy D, Tarbell KV Diabetologia

Phase Ib Study of Glasdegib, A Hedgehog Pathway Inhibitor, in (2018) Savona M, Pollyea D, Stock W, Oehler V, Schroeder MA, Lancet J, McCloskey J, Kantarigian H, Ma WW, Shaik MN, Laird AD, Zeremski M, O'Connell A, Chan G, Cortes JE Clinical Cancer Research

Synergistic Cytokine Effects as Apremilast Response Predictors in Patients With Psoriasis (2018) Garcet S, Nograles K, Correa da Rosa J, Schafer PH, Krueger JG Journal of Allergy and Clinical Immunology

Serum Apolipoprotein E and Other Inflammatory Markers Can Identify Non-Responding Patients to a Dendritic Cell Vaccine (2018) Leeman H, Kaminska E, Green D, Bodman-Smith M, Gravett A, Bodman-Smith K, Copier J, Coulton G, Fusi A, Dalgleish AG Translational Oncology

Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome (2014) Steeb H, Ramsey JM, Guest PC, Stocki P, Cooper JD, Rahmoune H, Ingudomnukul E, Auyeung B, Ruta L, Baron-Cohen S, Bahn S Mol Autism. 2014 Jan 27;5(1):4

Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome (2014) Steeb H, Ramsey JM, Guest PC, Stocki P, Cooper JD, Rahmoune H, Ingudomnukul E, Auyeung B, Ruta L, Baron-Cohen S, Bahn S Mol Autism. 2014 Jan 27;5(1):4

Identification of Subgroups of Schizophrenia Patients with Changes in Either Immune or Growth Factor and Hormonal Pathways (2013) Schwarz E, Van Beveren NJM, Ramsey J, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Guest PC, Bahn S Schizophrenia Bulletin

Immunomodulatory Effect of the Topical Ophthalmic Janus Kinase Inhibitor Tofacitinib (CP-690,550) in Patients with Dry Eye Disease (2012) Huang JF, Yafawi R, Zhang M, McDowell M, Rittenhouse KD, Sace F, Liew SH, Cooper SR, Pickering EH Ophthalmology. 2012 Jul;119(7):e43-50

Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis (2011) Guglielmelli P, Barosi G, Rambaldi A, Marchioli R, Masciulli A, Tozzi L, Biamonte F, Bartalucci N, Gattoni E, Lupo ML, Finazzi G, Pancrazzi A, Antonioli E, Susini MC, Pieri L, Malevolti E, Usala E, Occhini U, Grossi A, Caglio S, Paratore S, Bosi A, Barbui T, Vannucchi AM Blood. 2011 Jul 1. [Epub ahead of print]

Sex-specific serum biomarker patterns in adults with Asperger's syndrome (2010) Schwarz E, Guest PC, Rahmoune H, Wang L, Levin Y, Ingudomnukul E, Ruta L, Kent L, Spain M, Baron-Cohen S, Bahn S Mol Psychiatry. 2010 Sep 28. [Epub ahead of print]

Feasibility of FDG imaging of the coronary arteries: comparison between acute coronary syndrome and stable angina. (2010) Rogers IS, Nasir K, Figueroa AL, Cury RC, Hoffmann U, Vermylen DA, Brady TJ, Tawakol A JACC Cardiovasc Imaging 3: 388-397.

"Host Tissue Damage" Signal ATP Impairs IL-12 and IFNgamma Secretion in LPS Stimulated Whole Human Blood. (2008) Nalos M, Huang S, Sluyter R, Khan A, Santner-Nanan B, Nanan R, McLean AS Intensive Care Med 34: 1891-1897.

Neighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells. (2007) Caers J, Deleu S, Belaid Z, De Raeve H, Van Valckenborgh E, De Bruyne E, Defresne MP, Van Riet I, Van Camp B, Vanderkerken K Leukemia 21: 1580-1584.