Insulin-like Growth Factor I

Insulin-like Growth Factor I (IGF-I)

Insulin-like Growth Factor I (IGF-1) is produced by the liver and target tissues. Production is stimulated by growth hormone and retarded by undernutrition. A large fraction of circulating IGF-1 is complexed with IGF binding proteins. IGF-I is closely related to a second protein, IGF-II. IGF-II also binds the IGF-1 Receptor, and mediates growth in the same way that IGF-I does. However, IGF-2 alone binds the IGF II receptor (also called the Mannose-6 phosphate receptor), that appears to be a non-signaling receptor. IGF-I is produced throughout life with the highest rates of IGF-I production occurring during the pubertal growth spurt and the lowest levels occurring during infancy and old age. IGF-I levels can be measured in the blood in 10-1000 ng/ml amounts. As levels do not fluctuate greatly throughout the day, IGF-I is used by physicians as a screening test for growth hormone deficiency and excess. As the name "insulin-like growth factor I" implies, IGF-I is structurally related to insulin and is even capable of binding the insulin receptor, albeit at lower affinity than insulin.

Swiss-Prot Accession Number: P01343

 

Product Associations

This analyte is not currently part of Myriad RBM's testing menu.

 

Publications

Biomarker Changes in Response to a 12-Week Supplementation of an Oral Nutritional Supplement Enriched with Protein, Vitamin D and HMB in Malnourished Community Dwelling Older Adults with Sarcopenia (2022) Suzette L. Pereira , Marni E. Shoemaker, Susan Gawel, Gerard J. Davis Menghua Luo, Vikkie A. Mustad and Joel T. Cramer Nutrients

Blood-based protein mediators of senility with replications across biofluids (2019) Royall DR, Palmer RF, The Alzheimer's Disease Neuroimaging Initiative Brain Communications

Serum Apolipoprotein E and Other Inflammatory Markers Can Identify Non-Responding Patients to a Dendritic Cell Vaccine (2018) Leeman H, Kaminska E, Green D, Bodman-Smith M, Gravett A, Bodman-Smith K, Copier J, Coulton G, Fusi A, Dalgleish AG Translational Oncology

Serum proteins mediate depression?s association with dementia (2017) Royall DR, Al-Rubaye S, Bishnoi R, Palmer RF Plos One

Assessment of Proteomic Measures Across Serious Psychiatric Illness. (2017) Schulz SC, Overgaard S, Bond DJ, Kaldate R. Clin Schizophr Relat Psychoses

Assessment of Urine Proteomics in Type 1 Primary Hyperoxaluria*American Journal of Nephrology (2016) Brooks ER, Hoppe B, Milliner DS, Salido E, Rim J, Krevitt LM, Olson JB, Price HE, Vural G, Langman CB American Journal of Nephrology

Multiplex immunoassay analysis of plasma shows prominent upregulation of growth factor activity pathways linked to GSK3? signaling in bipolar patients (2013) Haenisch F, Alsaif M, Guest PC, Rahmoune H, Dickerson F, Yolken R, Bahn S Journal of Affective Disorders

Blood profiling of proteins and steroids during weight maintenance with manipulation of dietary protein level and glycaemic index (2012) Wang P, Holst C, Astrup A, Bouwman FG, van Otterdijk S, Wodzig WK, Andersen MR, van Baak MA, Rasmussen LG, Martinez JA, Jebb SA, Pfeiffer AF, Kafatos A, Handjieva-Darlenska T, Hlavaty P, Saris WH, Mariman EC Br J Nutr. 2012 Jan;107(1):106-19

Electroconvulsive therapy exerts mainly acute molecular changes in serum of major depressive disorder patients (2012) Stelzhammer V, Guest PC, Rothermundt M, Sondermann C, Michael N, Schwarz E, Rahmoune H, Bahn S Eur Neuropsychopharmacol. 2012 Nov 22. pii: S0924-977X(12)00303-3

Bone Marrow Derived Mesenchymal Stromal Cells are Attracted by Multiple Myeloma Cell-Produced Chemokine CCL25 and Favor Myeloma Cell Growth In Vitro and In Vivo (2011) Xu S, Menu E, De Becker A, Van Camp B, Vanderkerken K, Van Riet I Stem Cells. 2011 Nov 18. [Epub ahead of print]

A novel detection method of non-small cell lung cancer using multiplexed bead-based serum biomarker profiling (2011) Lee HJ, Kim YT, Park PJ, Shin YS, Kang KN, Kim Y, Kim CW J Thorac Cardiovasc Surg. 2011 Nov 18. [Epub ahead of print]

Bevacizumab therapy normalizes the pathological intraocular environment beyond neutralizing VEGF (2010) Sharma RK, Rogojina AT, Chalam KV Mol Vi. 16: 2175-2184.

Classification of Alcohol Abuse by Plasma Protein Biomarkers. (2010) Freeman WM, Salzberg AC, Gonzales SW, Grant KA, Vrana KE Biol Psychiatry 68: 219-22.

Regression of Human Pancreatic Tumor Xenografts in Mice After a Single Systemic Injection of Recombinant Vaccinia Virus GLV-1h68. (2009) Yu YA, Galanis C, Woo Y, Chen N, Zhang Q, Fong Y, Szalay AA Mol Cancer Ther 8: 141-151.