Intercellular Adhesion Molecule 1 (ICAM-1)
Intercellular Adhesion Molecule 1 (ICAM-1) is a cell surface receptor molecule that is implicated in a number of cellular processes including inflammation, cardiovascular disease, diabetes, and metastasis of cancer. Its soluble form is a product of cleavage at the cell’s surface and this form may have either positive or negative feedback functions as found in the blood.
Swiss-Prot Accession Number: P05362
PublicationsCorrelative serum biomarker analyses in the phase 2 trial of lenvatinib-plus-everolimus in patients with metastatic renal cell carcinoma (2021) Lee CH, Motzer RJ, Glen H, Michaelson MD, Larkin J, Minoshima Y, Kanekiyo M, Ikezawa H, Sachdev P, Dutcus CE, Funashashi Y, Voss MH British Journal of Cancer
The Effect of a natural oral nutritional supplement on the level of intra-articular inflammatory mediators in patients with osteoarthritis of the knee (2021) Sharkey P, Shah Z, Gross M, Meade T, Davidoff S, Shohat N, Parvizi J Journal of Orthopaedic Experience and Innovation
Influence of Genetic Ancestry on Human Serum Proteome (2020) Sjaarda J, Gerstein HC, Kutalik Z, Mohammadi-Shemirani P, Pigeyre M, Hess S, Pare G The American Journal of Human Genetics
Biomarkers and overall survival in patients with advanced hepatocellular carcinoma treated with TGF-ßRI inhibitor galunisertib. (2020) Giannelli G, Santoro A, Kelley RK, Gane E, Paradis V, Cleverly A, Smith C, Estrem ST, Man M, Wang S, Lahn MM, Raymond E, Benhadji KA, Faivre S PLoS One
Inhibition of cytokine signaling by ruxolitinib and implactions for COVID-19 treatment (2020) Yeleswaram S, Smith P, Burn T, Covington M, Juvekar A, Li Y, Squier P, Langmuir P Clinical Immunology
Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation. (2019) Haraden CA, Huebner JL, Hsueh MF, Li YJ, Kraus VB Arthritis Research & Therapy
Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults. (2019) Diniz BS, Reynolds Iii CF, Sibille E, Bot M, Penninx BWJH Translational Psychiatry
Development of a prognostic composite cytokine signature based on the correlation with nivolumab clearance: translational PK/PD analysis in patients with renal cell carcinoma. (2019) Wang R, Zheng J, Shao X, Ishii Y, Roy A, Bello A, Lee R, Zhang J, Wind-Rotolo M, Feny Y Journal for ImmunoTherapy of Cancer
Phase Ib Study of Glasdegib, A Hedgehog Pathway Inhibitor, in (2018) Savona M, Pollyea D, Stock W, Oehler V, Schroeder MA, Lancet J, McCloskey J, Kantarigian H, Ma WW, Shaik MN, Laird AD, Zeremski M, O'Connell A, Chan G, Cortes JE Clinical Cancer Research
Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury (2018) Proudfood A, Bayliffe A, O'Kane C, Wright T, Serone A, Bareille P, Brown V, Hamid U, Chen Y, Wilson R, Cordy J, Morley P, de Wildt Ruud, Elborn S, Hind M, Chilvres E, Griffiths M, Summers C, McAuley D Thorax
Key Proteins Involed in Spheroid Formation and Angiogenesis in Endothelial Cells After Long-Term Exposure to Simulated Microgravity (2018) Dittrich A, Grimm D, Sahana J, Bauer J, Kruger M, Infanger M, Magnusson N Cellular Physiology and Biochemistry 2018
Evaluation of plasma biomarkers of inflammation in patients with maple syrup urine disease (2018) Scaini G, Tonon T, Moura de Souza CF, Schuck PF, Ferreira GC, Quevedo J, Seda Neto J, Amorim T, Camelo Jr JS, Vitoria Barban Margutti A, Hencke Tresbach R, Sperb-Ludwig F, Boy R, V. de Medeiros PF, Schwards IVD, Luiz Streck E Journal of Inherited Metabolic Disease
IL-17 blockade with secukinumab in peripheral spondyloarthritis impacts synovial immunopathology without compromising systemic immune responses (2018) van Mens LJJ, van de Sande MGH, Menegatti S, Chen S, Blijdorp ICP, de Jong HM, Fluri IA, Latuhihin TE, van Kuijk AWR, Rogge L, Yeremenko NG, Baeten DLP Arthritis Rheumatol
Synergistic Cytokine Effects as Apremilast Response Predictors in Patients With Psoriasis (2018) Garcet S, Nograles K, Correa da Rosa J, Schafer PH, Krueger JG Journal of Allergy and Clinical Immunology
Serum Apolipoprotein E and Other Inflammatory Markers Can Identify Non-Responding Patients to a Dendritic Cell Vaccine (2018) Leeman H, Kaminska E, Green D, Bodman-Smith M, Gravett A, Bodman-Smith K, Copier J, Coulton G, Fusi A, Dalgleish AG Translational Oncology
PF-04447943, a Phosphodiesterase 9A Inhibitor, in Stable Sickle Cell Disease Patients: A Phase Ib Randomized, Placebo-Controlled Study (2018) Charnigo RJ, Beidler D, Rybin D, Pittman DD, Tan B, Howard J, Michelson AD, Frelinger AL II, Clark N Clinical and Translational Science
Protein Biomarker Druggability Profiling (2017) Mani S, Cannon D, Ohls R, Oprea T, Mathias S, Ballard K, Ursu O, Bologa C J Biomed Inform
Soluble intercellular adhesion molecule-1: a potential biomarker for pain intensity in chronic pain patients. (2017) Luchting B, Hinske LC, Rachinger-Adam B, Celi LA, Kreth S, Azad SC Biomark Med
Inflammatory profile analysis reveals differences in cytokine expression between smokers, moist snuff users, and dual users compared to non-tobacco consumers. (2017) Sgambato JA, Jones BA, Caraway JW, Prasad GL Cytokine
High false-positive rate of a putative biomarker test to aid in the diagnosis of schizophrenia (2016) Wehler CA, Preskorn, SH Journal of Clinical Psychiatry
Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time (2016) Schild M, Eichner G, Beiter T, Zuegel M, Niess AM, Steinacker JM, Mooren FC Mediators of Inflammation
Assessment of Urine Proteomics in Type 1 Primary Hyperoxaluria*American Journal of Nephrology (2016) Brooks ER, Hoppe B, Milliner DS, Salido E, Rim J, Krevitt LM, Olson JB, Price HE, Vural G, Langman CB American Journal of Nephrology
Inflammatory Profile in Lrrk2-Associated Prodromal and Clinical Pd (2016) Brockmann K, Apel A, Schulte C, Schneiderhan-Marra N, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol J-C, Cormier F, Knorpp T, Joos TO, Gasser T, Schüle B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Marras C, Berg D, Maetzler W Journal of Neuroinflammation
Circulating Biomarkers and Outcome from a Randomised Phase Ii Trial of Sunitinib Vs Everolimus for Patients with Metastatic Renal Cell Carcinoma (2016) Voss MH, Chen D, Marker M, Hakimi AA, Lee C-H, Hsieh JJ, Knox JJ, Voi M, Motzer RJ British Journal of Cancer
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports
Blood-based immune-endocrine biomarkers of treatment response in depression (2016) Chan MK, Cooper JD, Bot M, Birkenhanger TK, Bergink V, Drexhage HA, Steiner J, Rothermundt M, Penninx BWJH, Bahn S Journal of Psychiatric Research
Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis. (2016) Amalakuhan B, Habib SA, Mangat M, Reyes LF, Rodriguez AH, Hinojosa CA, Soni NJ, Gilley RP, Bustamante CA, Anzueto A, Levine SM, Peters JI, Aliberti S, Sibila O, Chalmers JD, Torres A, Waterer GW, Martin-Loeches I, Bordon J, Blanquer J, Sanz F, Marcos PJ, Rello J, Ramirez J, Solé-Violán J, Luna CM, Feldman C, Witzenrath M, Wunderink RG, Stolz D, Wiemken TL, Shindo Y, Dela Cruz CS, Orihuela CJ, Restrepo MI. Cytokine
Serum biomarkers and changes in clinical/MRI evidence of golimumab-treated patients with ankylosing spondylitis: results of the randomized, placebo-controlled GO-RAISE study (2016) Inman RD, Baraliakos X, Hermann KA, Braun J, Deodhar A, Heijde D, Xu S, and Hsu B Arthritis Res Ther.
Characterizing the Inflammatory Response in Esophageal Mucosal Biopsies in Children with Eosinophilic Esophagitis (2016) Sayej WN, Menoret A, Maharjan AS, Fernandez M, Wang Z, Balarezo F, Hyams JS, Sylvester FA, Vella AT Clinical & Translational Immunology
THU0223 Serum Biomarkers Associated with Changes in Asdas and MRI Following Treatment of Ankylosing Spondylitis with Golimumab (2015) Inman RD, Baraliakos X, Hermann KG, Braun J, Deodhar A, van der Heijde DF, Xu S, Hsu B Ann Rheum Dis
Markers of inflammation are associated with clinical outcomes in patients with metastatic renal cell carcinoma treated with nivolumab (2015) Sznol M, Fishman M, Escudier B, McDermott DF, Kluger H, Stadler WM, Perez-Gracia J, McNeel DG, Curti BD, Harrison MR, Plimack ER, Appleman L, Fong L, Drake CG, Young TC, Chasalow SD, Ross-MacDonald P, Simon JS, Walker D, Choueiri TK J Immunother Cancer
Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges (2015) O'Bryant SE, Listac S, Rissman RA, Edwards M, Zhang F, Hall J, Zetterberg H, Lovestone S, Gupta V, Graff-Radford N, Martins R, Jeromin A, Waring S, Oh E, King M, Baker L, Hampel H Alzheimers Dement (2015) 1-8
Plasma Inflammatory Factors Are Associated with Anxiety, Depression, and Cognitive Problems in Adults with and without Methamphetamine Dependence: An Exploratory Protein Array Study (2015) Huckans M, Fuller BE, Chalker ALN, Adams M, Loftis JM Frontiers in Psychiatry
Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome (2014) Steeb H, Ramsey JM, Guest PC, Stocki P, Cooper JD, Rahmoune H, Ingudomnukul E, Auyeung B, Ruta L, Baron-Cohen S, Bahn S Mol Autism. 2014 Jan 27;5(1):4
The Human Salivary Proteome is Radiation Responsive (2014) Moore HD, Ivey RG, Voytovich UJ, Lin C, Stirewalt DL, Pogosova-Agadjanyan EL, Paulovich AG Radiat Res. 2014 Apr 10. [Epub ahead of print]
The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes (2014) Carolan BJ, Hughes G, Morrow J, Hersh CP, O'Neal WK, Rennard S, Pillai SG, Belloni P, Cockayne DA, Comellas AP, Han M, Zemans RL, Kechris K, Bowler RP. Respiratory Research 2014 Oct 12;15(1):127. doi: 10.1186/s12931-014-0127-9.
Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome (2014) Steeb H, Ramsey JM, Guest PC, Stocki P, Cooper JD, Rahmoune H, Ingudomnukul E, Auyeung B, Ruta L, Baron-Cohen S, Bahn S Mol Autism. 2014 Jan 27;5(1):4
Distinctive Colonic Mucosal Cytokine Signature in New-Onset, Untreated Pediatric Crohn Disease (2014) Sylvester FA, Draghi A, Menoret A, Fernandez ML, Wang Z, Vella AT Journal of Pediatric Gastroenterology and Nutrition
Identification of a molecular profile associated with immune status in first onset schizophrenia patients (2013) Herberth M, Rahmoune H, Schwarz E, Koethe D, Harris LW, Kranaster L, Witt SH, Spain M, Barnes A, Schmolz M, Leweke MF, Guest PC, Bahn S Clin Schizophr Relat Psychoses
Distinct Molecular Phenotypes in Male and Female Schizophrenia Patients (2013) Ramsey JM, Schwarz E, Guest PC, Van Beveren NJM, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Bahn S PLoS ONE
Highly aggregated antibody therapeutics can enhance the in vitro innate and late-stage T-cell immune responses (2012) Joubert MK, Hokom M, Eakin C, Zhou L, Deshpande M, Baker MP, Goletz TJ, Kerwin BA, Chirmule N, Narhi LO, Jawa V J Biol Chem. 2012 Jul 20;287(30):25266-79
Biomarkers and Depressive Symptoms in Older Women with and without Cognitive Impairment (2012) Hall JR, Johnson LA, Vo HT, Barber RC, Winter AS, O’Bryant SE Journal of Behavioral and Brain Science, 2012, 2, 276-281
Expanding the Psoriasis Disease Profile: Interrogation of the Skin and Serum of Patients with Moderate-to-Severe Psoriasis (2012) Suárez-Fariñas M, Li K, Fuentes-Duculan J, Hayden K, Brodmerkel C, Krueger JG J Invest Dermatol. 2012 Jul 5
Markers of inflammation and bone remodelling associated with improvement in clinical response measures in psoriatic arthritis patients treated with golimumab (2012) Wagner CL, Visvanathan S, Elashoff M, McInnes IB, Mease PJ, Krueger GG, Murphy FT, Papp K, Gomez-Reino JJ, Mack M, Beutler A, Gladman D, Kavanaugh A Ann Rheum Dis. 2012 Sep 12. [Epub ahead of print]
Neuroinflammatory phenotype in early Alzheimer's disease (2012) Sudduth TL, Schmitt FA, Nelson PT, Wilcock DM Neurobiol Aging. 2012 Oct 9. pii: S0197-4580(12)00468-X
Sublytic Concentrations of Staphylococcus Aureus Panton-Valentine Leukocidin Alter Human Pmn Gene Expression and Enhance Bactericidal Capacity (2012) Graves SF, Kobayashi SD, Braughton KR, Whitney AR, Sturdevant DE, Rasmussen DL, Kirpotina LN, Quinn MT, Deleo FR Journal of Leukocyte Biology
Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV (2011) Casrouge A, Decalf J, Ahloulay M, Lababidi C, Mansour H, Vallet-Pichard A, Mallet V, Mottez E, Mapes J, Fontanet A, Pol S, Albert ML J Clin Invest. 121: 308-317.
Peripheral Blood Proteins Predict Mortality in Idiopathic Pulmonary Fibrosis (2011) Richards TJ, Kaminski N, Baribaud F, Flavin S, Brodmerkel C, Horowitz D, Li K, Choi J, Vuga LJ, Lindell KO, Klesen M, Zhang Y, Gibson KF Am J Respir Crit Care Med. 2011 Oct 20. [Epub ahead of print]
Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis (2011) Guglielmelli P, Barosi G, Rambaldi A, Marchioli R, Masciulli A, Tozzi L, Biamonte F, Bartalucci N, Gattoni E, Lupo ML, Finazzi G, Pancrazzi A, Antonioli E, Susini MC, Pieri L, Malevolti E, Usala E, Occhini U, Grossi A, Caglio S, Paratore S, Bosi A, Barbui T, Vannucchi AM Blood. 2011 Jul 1. [Epub ahead of print]
Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis (2010) Verstovsek S, Kantarjian H, Mesa RA, Pardanani AD, Cortes-Franco J, Thomas DA, Estrov Z, Fridman JS, Bradley EC, Erickson-Viitanen S, Vaddi K, Levy R, Tefferi A N Engl J Med. 363: 1117-27.
Validation of a Blood-Based Laboratory Test to Aid in the Confirmation of a Diagnosis of Schizophrenia (2010) Schwarz E, Izmailov R, Spain M, Barnes A, Mapes JP, Guest PC, Rahmoune H, Pietsch S, Leweke FM, Rothermundt M, Steiner J, Koethe D, Kranaster L, Ohrmann P, Suslow T, Levin Y, Bogerts B, (JM) van Beveren N, McAllister G, Weber N, Niebuhr D, Cowan D, Yolken RH, Bahn S Biomark Insights5: 39–47.
Association of serum markers with improvement in clinical response measures after treatment with golimumab in patients with active rheumatoid arthritis despite receiving methotrexate: results from the GO-FORWARD study (2010) Visvanathan S, Rahman MU, Keystone E, Genovese M, Klareskog L, Hsia E, Mack M, Buchanan J, Elashoff M, Wagner C Arthritis Res Ther. 12:R211
Bevacizumab therapy normalizes the pathological intraocular environment beyond neutralizing VEGF (2010) Sharma RK, Rogojina AT, Chalam KV Mol Vi. 16: 2175-2184.
Limited Systemic Sclerosis Patients with Pulmonary Arterial Hypertension Show Biomarkers of Inflammation and Vascular Injury (2010) Pendergrass SA, Hayes E, Farina G, Lemaire R, Farber HW, Whitfield ML, Lafyatis R. PLoS ONE 5: e12106.
Cholesterol in human atherosclerotic plaque is a marker for underlying disease state and plaque vulnerability (2010) Chen Z, Ichetovkin M, Kurtz M, Zycband E, Kawka D, Woods J, He X, Plump AS, Hailman E Lipids Health Dis 11: 61.
Sex-specific serum biomarker patterns in adults with Asperger's syndrome (2010) Schwarz E, Guest PC, Rahmoune H, Wang L, Levin Y, Ingudomnukul E, Ruta L, Kent L, Spain M, Baron-Cohen S, Bahn S Mol Psychiatry. 2010 Sep 28. [Epub ahead of print]
Metronomic Gemcitabine Suppresses Tumour Growth, Improves Perfusion, and Reduces Hypoxia in Human Pancreatic Ductal Adenocarcinoma (2010) Cham KKY, Baker JHE, Takhar KS, Flexman JA, Wong MQ, Owen DA, Yung A, Kozlowski P, Reinsberg SA, Chu EM, Chang CWA, Buczkowski AK, Chung SW, Scudamore CH, Minchinton AI, Yapp DTT, Ng SSW British Journal of Cancer
Identifying early markers of Alzheimer's disease using quantitative multiplex proteomic immunoassay panels (2009) Soares HD, Chen Y, Sabbagh M, Roher A, Schrijvers E, Breteler M Ann N Y Acad Sci. 1180 :56-67.
Molecular Response to Cetuximab and Efficacy of Preoperative Cetuximab-Based Chemoradiation in Rectal Cancer. (2009) Debucquoy A, Haustermans K, Daemen A, Aydin S, Libbrecht L, Gevaert O, De Moor B, Tejpar S, McBride WH, Penninckx F, Scalliet P, Stroh C, Vlassak S, Sempoux C, Machiels JP J Clin Oncol 27: 2751-2757.