Fatty Acid-Binding Protein, heart

Fatty Acid-Binding Protein, heart (FABP, heart)

Fatty Acid-Binding Protein, heart (H-FABP) is a plasma marker of acute myocardial infarction (AMI). The plasma kinetics of H-FABP closely resemble those of myoglobin in that elevated plasma concentrations are found within two hours after AMI and return to normal generally within 18 to 24 hours. The concentration of H-FABP in skeletal muscle is 20 times lower than in cardiac tissue (for myoglobin the same content for cardiac and skeletal tissue). This makes FABP a useful biochemical marker for the early assessment or exclusion of AMI. H-FABP also appears to be a useful plasma marker for the estimation of cardiovascular risk.

Swiss-Prot Accession Number: P05413

Publications

Relationship between cerebrospinal fluid neurodegeneration biomarkers and temporal brain atrophy in cognitively healthy older adults (2022) DidacVidal-Pi?eiro, ?ysteinS?rensen, KajBlennow, Elettra Capogna, Nathalie Bodd Halaas, Ane-VictoriaId, Athanasia Monica Mowinckel, Joana Braga Pereira, Leiv Otto Watne, Henrik Zetterberg, Kristine Beate Walhovd, Anders Martin Fjell Neurobiology of Aging

Hypothesis: cerebrospinal fluid protein markers suggest a pathway toward symptomatic resilience to AD pathology (2019) Meyer PF, Savard M, Poirier J, Morgan D, Breitner J, for the Alzheimer's Disease Neuroimaging Initiative Alzheimer's & Dementia

Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time (2016) Schild M, Eichner G, Beiter T, Zuegel M, Niess AM, Steinacker JM, Mooren FC Mediators of Inflammation

Early Role of Vascular Dysregulation on Late-Onset Alzheimer's Disease Based on Multifactorial Data-Driven Analysis (2016) Iturria-Medina Y, Sotero RC, Toussaint PJ, Mateos-Perez JM, Evans AC, The Alzheimer's Disease Neuroimaging Initiative Nature Communications

Biomarkers of rapid chronic kidney disease progression in type 2 diabetes (2015) Looker HC, Colombo M, Hess S, Brosnan MJ, Farran B, Dalton RN, Wong MC, Turner C, Palmer CNA, Nogceke E, Groop L, Salomaa V, Dunger DB, Agakov F, McKeigue PM, Colhoun HM Kidney International

Pretreatment levels of the fatty acid handling proteins H-FABP and CD36 predict response to olanzapine in recent-onset schizophrenia patients (2015) Tomasik J, Schwarz E, Lago SG, Rothermundt M, Leweke FM, van Beveren NJ, Guest PC, Rahmoune H, Steiner J, Bahn S. Brain Behav Immun.

Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges (2015) O'Bryant SE, Listac S, Rissman RA, Edwards M, Zhang F, Hall J, Zetterberg H, Lovestone S, Gupta V, Graff-Radford N, Martins R, Jeromin A, Waring S, Oh E, King M, Baker L, Hampel H Alzheimers Dement (2015) 1-8

Heart-type fatty acid binding protein and vascular endothelial growth factor: cerebrospinal fluid biomarker candidates for Alzheimer?s disease (2013) Guo L, Alexopoulos P, Perneczky R European Archives of Psychiatry and Clinical Neuroscience

Identification of blood-based molecular signatures for prediction of response and relapse in schizophrenia patients (2012) Schwarz E, Guest PC, Steiner J, Bogerts B, Bahn S Translational Psychiatry (2012) 2, e82

Screening for New Biomarkers for Subcortical Vascular Dementia and Alzheimer?s Disease (2011) ?hrfelt A, Andreasson U, Simon A, Zetterberg H, Edman A, Potter W, Holder D, Devanarayan V, Seeburger J, Smith AD, Blennow K, Wallin A Dement Geriatr Cogn Disord Extra 1: 31?42.

Inflammatory and Hemostatic Response to Cardiopulmonary Bypass in Pediatric Population: Feasibility of Seriological Testing of Multiple Biomarkers (2010) Agirbasli M, Nguyen ML, Win K, Kunselman AR, Clark JB, Myers JL, Undar A Artif Organs. 34: 987-95.

Plasma Protein Profiling Reveals Protein Clusters Related to BMI and Insulin Levels in Middle-Aged Overweight Subjects (2010) van Dijk SJ, Feskens EJM, Heidema AG, Bos MB, van de Rest O, Geleijnse JM, de Groot LCPGM, Muller M, Afman LA PLoS ONE 12: e14422.

Regression of Human Pancreatic Tumor Xenografts in Mice After a Single Systemic Injection of Recombinant Vaccinia Virus GLV-1h68. (2009) Yu YA, Galanis C, Woo Y, Chen N, Zhang Q, Fong Y, Szalay AA Mol Cancer Ther 8: 141-151.

Effects of the incubation in vitro with sorbents on serum proteomic pattern and cytokine concentration in cancer patients during chemotherapy--preliminary results. (2006) Piccolomini F, LouWratten M, Sereni L, Balestreri E, Donadio E, Felicioli A, Felicioli R, Donadio C Biomed Pharmacother 60: 463-467.