FASLG Receptor (FAS)

FASLG (FAS) receptor, also known as APO-1 antigen, CD95, and TNFRSF6, is a 45-kd, transmembrane protein receptor that belongs to the TNF and NGF receptor family. The FASLG Receptor and its ligand (FasL) exist in both membrane-bound and soluble forms. Membrane-bound Fas is the natural ligand for soluble FasL. Apoptosis is induced when membrane-bound or soluble FasL binds to Fas receptor-bearing cells resulting in the activation of the caspase cascade. Fas is highly expressed in epithelial cells, hepatocytes, activated mature lymphocytes, tumor cells, as well as throughout the CNS. Expression of FASLG and FasL is significantly elevated in a variety of neurological disorders, suggesting that this system may play a role in degenerative responses in the CNS.

Swiss-Prot Accession Number: P25445

Therapy Indications
Myriad RBM Publications Publications
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Networks of blood proteins in the neuroimmunology of schizophrenia (2018) Jeffries CD, Perkins DO, Fournier M, Do KQ, Cuenod M, Khadimallah I, Domenici E, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Mathalon DH, McGlashan TH, Seidman LJ, Tsuang M, Walker EF, Woods SW Transl Psychiatry
Serum proteins mediate depression’s association with dementia (2017) Royall DR, Al-Rubaye S, Bishnoi R, Palmer RF Plos One
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports
Angiogenesis Dysregulation in Term Asphyxiated Newborns Treated with Hypothermia (2015) Shaikh H, Boudes E, Khoja Z, Shevell M, Wintermark P PLOS One
Multiplexed Immunoassay Panel Identifies Novel CSF Biomarkers for Alzheimer's Disease Diagnosis and Prognosis (2011) Craig-Schapiro R, Kuhn M, Xiong C, Pickering EH, Liu J, Misko TP, Perrin RJ, Bales KR, Soares H, Fagan AM, Holtzman DM PLoS One. 2011 Apr 19;6(4):e18850