N-terminal prohormone of brain natriuretic peptide (NT proBNP)
Both N-terminal prohormone of brain natriuretic peptide (NT proBNP) and Brain Natriuretic Peptide (BNP) levels in the blood are used for screening and diagnosis of acute congestive heart failure and may be useful to establish prognosis in heart failure since both markers are typically higher in patients with worse outcome. The plasma concentrations of both BNP and NT proBNP are also typically increased in patients with asymptomatic or symptomatic left ventricular dysfunction.
Swiss-Prot Accession Number: P16860
PublicationsNT-proBNP versus routine clinical risk factors as a predictor of cardiovascular events or death in people with dysglycemia ? A brief report from the ORIGIN trial (2021) Wijkman MO, Claggett BL, Pfeffer MA, Pare G, McQueen M, Hess S, Fu Lee S, Gerstein HC Journal of Diabetes and its Complications
Identifying early pulmonary arterial hypertension biomarkers in systemic sclerosis: Machine learning on proteomics from the DETECT cohort (2020) Bauer Y, de Bernard S, Hickey P, Ballard K, Cruz J, Cornelisse P, Chadha-Boreham H, Distler O, Rosenberg D, Doelberg M, Roux S, Nayler O, Lawrie A European Respiratory Journal
TGFb receptor inhibitor galunisertib is linked to inflammation- and remodeling-related proteins in patients with pancreatic cancer (2019) Melisi D, Garcia-Carbonero R, Macarulla T, Pezet D, Deplangue G, Fuchs M, Trojan J, Kozloff M, Simionato F, Cleverly A, Smith C, Wang S, Man M, Driscoll KE, Estrem ST, Lahn MMF, Benhadji KA, Tabernero J Cancer Chemotherapy and Pharmacology
Biomarker panels associated with progression of renal disease in type 1 diabetes. (2019) Colombo M, Valo E, McGurnaghan SJ, Sandholm N, Blackbourn LAK, Dalton RN, Dunger D, Groop PH, McKeigue PM, Forsblom C, Colhoun HM Diabetologia
Novel Biomarkers for Change in Renal Function in People With Dysglycemia. (2019) Gerstein HC, Pare G, McQueen MJ, Lee SF, Bangdiwala SI, Kannt A, Hess A, ORIGIN Trial Investigators Diabetes Care
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort (2018) Labaki WW, Xia M, Murray S, Curtis JL, Barr RG, Bhatt SP, Bleecker ER, Hansel NN, Cooper CB, Dransfield MT, Wells JM, Hoffman EA, Kanner RE, Paine III R, Ortega VE, Peters SP, Krishnan JA, Bowler RP Respiratory Medicine
Association between Cytokines and Functional, Hemodynamic Parameters, and Clinical Outcomes in Pulmonary Arterial Hypertension (2018) Joshi AA, Davey RA, Rao Y, Shen K, Benza R, Raina A Pulmonary Circulation
Serum kidney injury molecule 1 and B2-microglobulin perform as well as larger biomarker panels for prediction of rapid decline in renal function in type 2 diabetes (2018) Colombo M, Looker HC, Farran B, Hess S, Groop L, Palmer CNA, Brosnan MJ, Dalton RN, Wong M, Turner C, Ahlqvist E, Dunger D, Agakov F, Durrington P, Livingstone S, Betteridge J, McKeigue PM, Colhoun HM Diabetologia
Multiple biomarker panel to screen for severe aortic stenosis: results from the CASABLANCA study (2018) Elmariah S, McCarthy C, Ibrahim N, Furman D, Mukai R, Magaret C, Rhyne R, Barnes G, van Kimmenade RRJ, Januzzi Jr JL Open Heart
Usefulness of Multiple Biomarkers for Predicting Incident Major Adverse Cardiac Events in Patients Undergoing Diagnostic Coronary Angiography (From the Catheter Sampled Blood Archive in Cardiovascular Diseases [CASABLANCA] Study) (2017) McCarthy CP, Van Kimmenade R, Gaggin HK, Simon ML, Ibrahim NE, Gandhi P, Kelly N, Motiwala SR, Belcher AM, Harisiades J, Magaret CA, Rhyne RF, Januzzi Jr. JL Am J Cardiol
Neuronal Pentraxin 2 predicts medial temporal atrophy and memory decline across the Alzheimer's disease spectrum. (2017) Swanson A, Willette AA; Alzheimer?s Disease Neuroimaging Initiative. Brain Behav Immun.
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports
Biomarkers of rapid chronic kidney disease progression in type 2 diabetes (2015) Looker HC, Colombo M, Hess S, Brosnan MJ, Farran B, Dalton RN, Wong MC, Turner C, Palmer CNA, Nogceke E, Groop L, Salomaa V, Dunger DB, Agakov F, McKeigue PM, Colhoun HM Kidney International
Identifying Novel Biomarkers for Cardiovascular Events or Death in People with Dysglycemia (2015) Gerstein HC, Par? G, Mcqueen MJ, Haenel H, Lee SF, Pogue J, Maggioni AP, Yusuf S, Hess S Circulation
Serum Proteomic Profiling of Major Depressive Disorder (2015) Bot M, Chan MK, Jansen R, Lamers F, Vogelzangs N, Steiner J, Leweke FM, Rothermundt M, Cooper J, Bahn S, Penninx BWJH Translational Psychiatry
Allogeneic mesenchymal stem cell infusion for the stabilization of focal segmental glomerulosclerosis (2013) Belingheri M, Lazzari L, Parazzi V, Groppali E, Biagi E, Gaipa G, Giordano R, Rastaldi MP, Croci D, Biondi A, Rebulla P, Edefonti A, Ghio L Biologicals. 2013 Oct 14. pii: S1045-1056(13)00111-5. doi: 10.1016/j.biologicals.2013.09.004
Plasma Biomarkers Associated With the Apolipoprotein E Genotype and Alzheimer Disease (2012) Soares HD, Potter WZ, Pickering E, Kuhn M, Immermann FW, Shera DM, Ferm M, Dean RA, Simon AJ, Swenson F, Siuciak JA, Kaplow J, Thambisetty M, Zagouras P, Koroshetz WJ, Wan HI, Trojanowski JQ, Shaw LM; for the Biomarkers Consortium Alzheimer's Disease Plasma Proteomics Project Arch Neurol. 2012 Jul 16:1-8
Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease (2012) Hu WT, Holtzman DM, Fagan AM, Shaw LM, Perrin R, Arnold SE, Grossman M, Xiong C, Craig-Schapiro R, Clark CM, Pickering E, Kuhn M, Chen Y, Van Deerlin VM, McCluskey L, Elman L, Karlawish J, Chen-Plotkin A, Hurtig HI, Siderowf A, Swenson F, Lee VM, Morris JC, Trojanowski JQ, Soares H; Alzheimer's Disease Neuroimaging Initiative Neurology. 2012 Aug 28;79(9):897-905
Multiplexed Immunoassay Panel Identifies Novel CSF Biomarkers for Alzheimer's Disease Diagnosis and Prognosis (2011) Craig-Schapiro R, Kuhn M, Xiong C, Pickering EH, Liu J, Misko TP, Perrin RJ, Bales KR, Soares H, Fagan AM, Holtzman DM PLoS One. 2011 Apr 19;6(4):e18850