Alpha-1-Antichymotrypsin (AACT)
Alpha 1-antichymotrypsin (AACT) is an acute phase protein produced in the liver and a deficiency of the protein has been associated with liver disease. Mutations in AACT have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. The serpin 1-antichymotrypsin is a major component of brain amyloid plaques in Alzheimer's disease. In vitro, AACT interacts with the Alzheimer's amyloid peptide A1-42 to stimulate both formation and disruption of neurotoxic A1-42 fibrils in a concentration-dependent manner. In the blood, AACT inhibits the activity of cathepsin G and chymases.
Swiss-Prot Accession Number: P01011
Product AssociationsThis analyte is not currently part of Myriad RBM's testing menu.
PublicationsInvestigating data-driven biological subtypes of sychiatric disorders using specification-curve analysis (2020) Beijers L, van Loo HM, Romeijn JW, Lamers F, Schoevers RA, Wardenaar KJ Psychological Medicine
Metabolomic analyses reveal lipid abnormalities and hepatic dysfunction in non-human primate model for Yersinia pestis (2019) Gautam A, Muhie S, Cakraborty N, Hoke A, Donohue D, Miller SA, Hammamieh R, Jett M Metabolomics
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports
Serum Proteomic Profiles of Depressive Subtypes (2016) Lamers F, Bot M, Jansen R, Chan MK, Cooper JD, Bahn S, Penninx BWJH Translational Psychiatry
Serum Proteomic Profiling of Major Depressive Disorder (2015) Bot M, Chan MK, Jansen R, Lamers F, Vogelzangs N, Steiner J, Leweke FM, Rothermundt M, Cooper J, Bahn S, Penninx BWJH Translational Psychiatry
Multiple sclerosis: Identification and clinical evaluation of novel CSF biomarkers (2010) Ottervald J, Franz?n B, Nilsson K, Andersson LI, Khademi M, Eriksson B, Kjellstr?m S, Marko-Varga G, V?gv?ri A, Harris RA, Laurell T, Miliotis T, Matusevicius D, Salter H, Ferm M, Olsson T J Proteomics73: 1117-32.