Bibliography

Cardiovascular

2023

Biomarkers Associated With Severe COVID-19 Among Populations With High Cardiometabolic Risk: A 2-Sample Mendelian Randomization Study (2023) Tushar Sood, Nicolas Perrot, Michael Chong, Pedrum Mohammadi-Shemirani, Maha Mushtaha, Darryl Leong, Sumathy Rangarajan, Sibylle Hess, Salim Yusuf, Hertzel C Gerstein, Guillaume Par?, Marie Pigeyre JAMA Network

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2022

Harnessing the Plasma Proteome to Mirror Current and Predict Future Cardiac Remodeling After Myocardial Infarction (2022) Upendra Chalise, Mediha Becirovic-Agic, Jocelyn R. Rodriguez-Paar, Shelby R. Konfrst, Sharon D. B. de Morais, Catherine S. Johnson, Elizabeth R. Flynn, Michael E. Hall, Daniel R. Anderson, Leah M. Cook, Kristine Y. DeLeon-Pennell & Merry L. Lindsey Journal of Cardiovascular Translational Research

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2021

NT-proBNP versus routine clinical risk factors as a predictor of cardiovascular events or death in people with dysglycemia ? A brief report from the ORIGIN trial (2021) Wijkman MO, Claggett BL, Pfeffer MA, Pare G, McQueen M, Hess S, Fu Lee S, Gerstein HC Journal of Diabetes and its Complications

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2020

Nasal Microbiota Modifies the Effects of Particulate Air Pollution on Plasma Extracellular Vesicles. (2020) Mariana J, Favero C, Carungno M, Pergoli L, Ferrari L, Bonzini M, Cattaneo A, Pesatori AC, Bollati V International Journal of Environmental Research and Public Health
 
Therapy Indications
Cardiovascular
Miscellaneous
 

Dynamic Aspects of Associations in Coronary Artery Disease: From Intracoronary Imaging to Blood Biomarkers (2020) Buljubasic, N. Erasmus University Rotterdam
 
Therapy Indications
 

Influence of Genetic Ancestry on Human Serum Proteome (2020) Sjaarda J, Gerstein HC, Kutalik Z, Mohammadi-Shemirani P, Pigeyre M, Hess S, Pare G The American Journal of Human Genetics
 
Therapy Indications
Cardiovascular
Miscellaneous
 

Molecular Epidemiology of Inflammation Link with Type 2 Diabetes and Coronary Heart Disease (2020) Ligthart S Erasmus University Rotterdam

Reduced chronic toxicity and carcinogenicity in A/J mice in response to life-time exposure to aerosol from a heated tobacco product compared with cigarette smoke (2020) Wong ET, Luettch K, Krishan S, Wong SK, Lim WT, Yeo D, Buttner A, Leroy P, Vuillaume G, Boue S, Hoeng J, Vansheeuwijck P, Peitsch M Toxicological Sciences
 
Therapy Indications
 

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals (2020) Fokersen L, Gustafsson S, Qang Q, Hansen DH, Hedman AK, Schork A, Page K, Zhernakova DV, Wu Y, Peteres J, Eriksson N, Bergen SE, Boutin TS, Bretherick AD, Entroth S, Kalnapenkis A, Gadin JR, Suur BE, Chen Y, Matic L, Gale JD, Lee J, Zhang W, Quazi A, Ala-Korpela M, Choi SH, Claringbould A, Danesh J, Smith GD, de Masi F, Elmstahl S, Engstrom G, Fauman E, Fernandez C, Franke L, Franks PW, Giedraitis V, Haley C, Hamsten A, Ingason A, Johansson A, Joshi PK, Lind L, Lindgren CM, Lubitz S, Palmer T, Macdonald-Dunlop E, Magnusson M, Melander O, Michaelsson K, Morris AP, Magi R, Nagle MW, Nilsson PM, Nilsson J, Orho-Melander M, Polasek O, Prins B, Palsson E, Qi T, Sjogren M, Sundstrom J, Surendran P, Vosa U, Werge T, Wernersson R, Westra HJ, Yang J, Zhernakova A, Arnlov J, Fu J, Smith JG, Esko T, Hayward C, Gyllensten U, Landen M, Siegbahn A, Wilson JF, Wallentin L, Butterworth AS, Homes MV, Ingelsson E, Malarstig A Nature Metabolism
 
Therapy Indications
 

Left and right atrial biomarker analysis in atrial fibrillation (2020) Goldberger JJ, Green D, Ringwala S, Andrei AC, Xu Y, Passman R JACC Clinical Electrophysiology
 
Therapy Indications
 

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2019

Performance of a clinical/proteomic panel to predict obstructive peripheral artery disease in patients with and without diabetes (2019) McCarthy CP, Shrestha S, Ibrahim N, van Kimmenade RRJ, Gaggin HK, Mukai R, Magaret C, Barnes G, Rhyne R, Garasic JM, Januzzi JL Open Heart

Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome. (2019) Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Pare G Circulation
 
Therapy Indications
 

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2018

Von Willebrand factor and ADAMTS13 activity in relation to risk of dementia: a population-based study (2018) Wolters F, Boender J, de Vries P, Sonneveld M, Koudstaal P, de Maat M, Franco O, Ikram M, Leebeek F, Ikram MA Scientific Reports 2018 Apr
 
Therapy Indications
 

Key Proteins Involed in Spheroid Formation and Angiogenesis in Endothelial Cells After Long-Term Exposure to Simulated Microgravity (2018) Dittrich A, Grimm D, Sahana J, Bauer J, Kruger M, Infanger M, Magnusson N Cellular Physiology and Biochemistry 2018
 
 

Carbon nanotube and nanofiber exposure and sputum and blood biomarkers of early effect among U.S. workers (2018) Beard JD, Erdely A, Dahm MM, de Perio MA, Birch ME, Evans DE, Fernback JE, Eye T, Kodali V, Mercer RR, Bertke SJ, Schubauer-Berigan MK Environmental Internation 116 (2018)

Anemia and Adverse Outcomes in a Chronic Obstructive Pulmonary Disease Population with a High Burden of Comorbidities (2018) Putcha N, Fawzy A, Paul GG, Lambert AA, Psoter KJ, Sidhaye VK, Woo J, Wells JM, Labaki WW, Doerschuk CM, Kanner RE, Han MK, Martinez C, Paulin LM, Martinez FJ, Wise RA, O'Neal WK, Barr RG, Hansei NN AnnalsATS
 
Therapy Indications
 

NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort (2018) Labaki WW, Xia M, Murray S, Curtis JL, Barr RG, Bhatt SP, Bleecker ER, Hansel NN, Cooper CB, Dransfield MT, Wells JM, Hoffman EA, Kanner RE, Paine III R, Ortega VE, Peters SP, Krishnan JA, Bowler RP Respiratory Medicine
 
Therapy Indications
 

Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome (2018) Lal C, Hardiman G, Kumbhare S, Strange C Sleep and Breathing
 
Therapy Indications
Cardiovascular
Miscellaneous
 

Blood CSF1 and CXCL12 as Causal Mediators of Coronary Artery Disease (2018) Sjaarda J, Gerstein H, Chong M, Yusuf S, Meyre D, Anand SS, Hess S, Pare G Journal of the American College of Cardiology
 
Therapy Indications
Cardiovascular
Miscellaneous
 

Associations of 26 Circulating Inflammatory and Renal Biomarkers with Near-Infrared Spectroscopy and Long-term Cardiovascular Outcome in Patients Undergoing Coronary Angiography (ATHEROREMO-NIRS Substudy) (2018) Anroedh SS, Akkerhuis KM, Oemrawsingh RM, Garcia-Garcia HM, Brankovic M, Regar E, van Geuns RJ, Serruys PW, Daemen J, Van Mieghem NM, Boersma E, Kardys I Current Atherosclerosis Reports
 
Therapy Indications
 

Adiponectin in Relation to Coronary Plaque Characteristics on Radiofrequency Intravascular Ultrasound and Cardiovascular Outcome (2018) Marino BCA, Buljubasic N, Akkerhuis M, Cheng JM, Garcia-Garcia HM, Regar E, van Guens RJ, Serruys PW, Boersma E, Kardys I Sociedade Brasileira De Cardiologia
 
Therapy Indications
 

Identifying the molecular and cellular signature of cardiac dilation following myocardial infarction (2018) Lindsey ML, Ma Y, Flynn ER, Winniford MD, Hall ME, DeLeon-Pennell KY BBA - Molecular Basis of Disease

Multiple biomarker panel to screen for severe aortic stenosis: results from the CASABLANCA study (2018) Elmariah S, McCarthy C, Ibrahim N, Furman D, Mukai R, Magaret C, Rhyne R, Barnes G, van Kimmenade RRJ, Januzzi Jr JL Open Heart
 
Therapy Indications
 

Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort (2018) Bhatt SP, Nath HP, Kim YI, Ramachandran R, Watts JR, Terry NLJ, Sonavane S, Deshmane SP, Woodruff PG, Oelsner EC, Bodduluri S, Han MK, Labaki WW, Michael Wells J, Martinez FJ, Barr RG, Dransfield MT, SPIROMICS investigators Respiratory Research

Testosterone, sex hormone-binding globulin and risk of cardiovascular events: A report from the Outcome Reduction with an Initial Glargine Intervention trial (2018) Wang A, Arver S, Boman K, Gerstein HC, Fu Lee S, Hess S, Ryden L, Mellbin LG Preventive Cardiology
 
Therapy Indications
 

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2017

Immunodepression after CPB: Cytokine dynamics and clinics after pediatric cardiac surgery ? A prospective trial (2017) Justus G, Walker C, Rosenthal LM, Berger F, Miera O, Schmitt KR Cytokine

Usefulness of Multiple Biomarkers for Predicting Incident Major Adverse Cardiac Events in Patients Undergoing Diagnostic Coronary Angiography (From the Catheter Sampled Blood Archive in Cardiovascular Diseases [CASABLANCA] Study) (2017) McCarthy CP, Van Kimmenade R, Gaggin HK, Simon ML, Ibrahim NE, Gandhi P, Kelly N, Motiwala SR, Belcher AM, Harisiades J, Magaret CA, Rhyne RF, Januzzi Jr. JL Am J Cardiol
 
Therapy Indications
 

Do single or sequential measurements of leptin and adiponectin in plasma have prognostic value in pulmonary arterial hypertension? (2017) Tonelli AR, Fares WH, Dakkak W, Rao Y, Zhou X, Dweik RA Pulm Circ
 
Therapy Indications
 

A randomised, placebo-controlled trial of anti-interleukin-1 receptor 1 monoclonal antibody MEDI8968 in chronic obstructive pulmonary disease. (2017) Calverley PMA, Sethi S, Dawson M, Ward CK, Finch DK, Penney M, Newbold P, van der Merwe R Respir Res.
 
Therapy Indications
 

Nintedanib macrophage activation and ameliorates vascular and fibrotic manifestations in the Fra2 mouse model of systemic sclerosis (2017) Huang J, Maier C, Zhang Y, Soare A, Dees C, Beyer C, Harre U, Chen CW, Distler O, Schett G, Wollin L, Distler JHW Ann Rheum Dis.
 
Therapy Indications
 

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2016

Apolipoprotein a-I and Paraoxonase-1 Are Potential Blood Biomarkers for Ischemic Stroke Diagnosis (2016) Walsh KB, Hart K, Roll S, Sperling M, Unruh D, Davidson WS, Lindsell CJ, Adeoye O Journal of Stroke and Cerebrovascular Diseases
 
 

Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time (2016) Schild M, Eichner G, Beiter T, Zuegel M, Niess AM, Steinacker JM, Mooren FC Mediators of Inflammation
 
Therapy Indications
 

Plasma cystatin C and neutrophil gelatinase-associated lipocalin in relation to coronary atherosclerosis on intravascular ultrasound and cardiovascular outcome: Impact of kidney function (ATHEROREMO-IVUS study). (2016) Brankovic M, Akkerhuis KM, Buljubasic N, Cheng JM, Oemrawsingh RM, Garcia-Garcia HM, Regar E, Serruys PW, van Geuns RJ, Boersma E, Kardys I. Atherosclerosis

Selective p38a MAP kinase/MAPK14 inhibition in enzymatically-modified LDL-stimulated human monocytes: implications for atherosclerosis. (2016) Cheng F, Twardowski L, Fehr S, Aner C, Schaeffeler E, Joos T, Knorpp T, Dorweiler B, Laufer S, Schwab M, Torzewski M. FASEB J
 
Therapy Indications
 

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2015

Nox4 supports proper capillary growth in exercise and retina neo-vascularization. (2015) Vogel J, Kruse C, Zhang M, Schr?der K. J Physiol. 2015 Feb 4. doi: 10.1113/jphysiol.2014.284901. [Epub ahead of print]
 
Therapy Indications
 

Protein biomarkers for the prediction of cardiovascular disease in type 2 diabetes. (2015) Looker HC, Colombo M, Agakov F, Zeller T, Groop L, Thorand B, Palmer CN, Hamsten A, de Faire U, Nogoceke E, Livingstone SJ, Salomaa V, Leander K, Barbarini N, Bellazzi R, van Zuydam N, McKeigue PM, Colhoun HM; on behalf of the SUMMIT Investigators. Diabetologia. 2015 Mar 5. [Epub ahead of print]

Study of cardiovascular disease biomarkers among tobacco consumers, part 2: biomarkers of biological effect. (2015) Nordskog BK, Brown BG, Marano KM, Campell LR, Jones BA, Borgerding MF. Inhal Toxicol. 2015 Mar 19:1-10. [Epub ahead of print]
 
Therapy Indications
 

Markers of atherosclerosis in relation to presence and progression of knee osteoarthritis: a population-based cohort study. (2015) Hoeven TA, Kavousi M, Ikram AM, van Meurs JB, Bindels PJ, Hofman A, Franco OH, Bierma-Zeinstra SM. Rheumatology (Oxford). 2015 May 6. pii: kev106. [Epub ahead of print]

Angiogenesis Dysregulation in Term Asphyxiated Newborns Treated with Hypothermia (2015) Shaikh H, Boudes E, Khoja Z, Shevell M, Wintermark P PLOS One
 
 

Novel data-mining approach identifies biomarkers for diagnosis of Kawasaki disease (2015) Tremoulet AH, Dutkowski J, Sato Y, Kanegaye JT, Ling XB, Burns JC Pediatr Res.

New biomarkers for primary mitral regurgitation (2015) Deroyer C, Magne J, Moonen M, Le Goff C, Dupont L, Hulin A, Radermecker M, Colige A, Cavalier E, Kolh P, Pierard L, Lancellotti P, Merville MP, Fillet M Clin Proteomics
 
Therapy Indications
 

MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis (2015) Ouimet M, Ediriweera HN, Gundra UM, Sheedy FJ, Ramkhelawon B, Hutchison SB, Rinehold K, van Solingen C, Fullerton MD, Cecchini K, Rayner KJ, Steinberg GR, Zamore PD, Fisher EA, Loke P, Moore KJ. J Clin Invest

Systems toxicology-based assessment of the candidate modified risk tobacco product THS2.2 for the adhesion of monocytic cells to human coronary arterial endothelial cells (2015) Poussin C, Laurent A, Peitsch MC, Hoeng J, and De Leon H Toxicology

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2014

The application of multiple reaction monitoring and multi-analyte profiling to HDL proteins (2014) Yassine HN, Jackson AM, Borges CR, Billheimer D, Koh H, Smith D, Reaven P, Lau SS, Borchers CH Lipids Health Dis. 2014 Jan 8;13(1):8

Plasma S100A12 is associated with functional outcome after ischemic stroke: Research for Biomarkers in Ischemic Stroke (2014) Wakisakaa Y, Agoa T, Kamouchib M, Kurodaa J, Matsuoa R, Hataa J, Gotoha S, Isomurad T, Awanod H, Suzukid, K, Fukudaa K, Okadaf Y, Kiyoharac Y, Ooboshig H, Kitazonoa T, on behalf of the REBIOS Investigators Journal of the Neurological Sciences 04 Mar 2014
 
Therapy Indications
 

Aliskiren and valsartan mediate left ventricular remodeling post-myocardial infarction in mice through MMP-9 effects (2014) Ramirez TA, Iyer RP, Ghasemi O, Lopez EF, Levin DB, Zhang J, Zamilpa R, Chou YM, Jin YF, Lindsey ML J Mol Cell Cardiol. 2014 Apr 22. pii: S0022-2828(14)00118-7
 
Therapy Indications
 

Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS) (2014) Matsuo R, Ago T, Kamouchi M, Kuroda J, Kuwashiro T, Hata J, Sugimori H, Fukuda K, Gotoh S, Makihara N, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T BMC Neurol. 2013 Apr 8;13:32
 
Therapy Indications
 

Neutrophils release extracellular DNA traps in response to exercise. (2014) Beiter T, Fragasso A, Hudemann J, Schild M, Steinacker J, Mooren FC, Niess AM. Journal of Applied Physiology 2014 Aug 1;117(3):325-33. doi: 10.1152/japplphysiol.00173.2014
 
Therapy Indications
 

Effects of alcohol and polyphenols from beer on atherosclerotic biomarkers in high cardiovascular risk men: a randomized feeding trial (2014) Chiva-Blancha G, Magraner E, Condines X, Valderas-Mart?nez P, Roth I, Arranz S, Casa R, Navarro M, Hervas A, Sis? A, Mart?nez-Hu?lamo M, Vallverd?-Queralt A, Quifer-Rada P, Lamuela-Raventos R-M, Estruch R Elsevier - Nutrition, Metabolism and Cardiovascular Diseases 2014 Aug 2; doi: 10.1016/j.numecd.2014.07.008
 
Therapy Indications
 

Chronic vagal stimulation for the treatment of low ejection fraction heart failure: results of the neural cardiac therapy for heart failure (NECTAR-HF) randomized controlled trial. (2014) Zannad F, De Ferrari GM, Tuinenburg AE, Wright D, Brugada J, Butter C, Klein H, Stolen C, Meyer S, Stein KM, Ramuzat A, Schubert B, Daum D, Neuzil P, Botman C, Caste MA, D'Onofrio A, Solomon SD1, Wold N, Ruble SB. European Heart Journal 2014 Aug 31. pii: ehu345. [Epub ahead of print]
 
Therapy Indications
 

Circulating chemokines in relation to coronary plaque characteristics on radiofrequency intravascular ultrasound and cardiovascular outcome. (2014) Cheng JM, Oemrawsingh RM, Akkerhuis KM, Garcia-Garcia HM, de Boer SP, Battes LC, Buljubasic N, Lenzen MJ, de Jaegere PP, van Geuns RJ, Serruys PW, Kardys I, Boersma E. Informa Healthcare Biomarkers 2014 Sep 8:1-9. [Epub ahead of print]
 
Therapy Indications
 

Fat Quality and Incident Cardiovascular Disease, All-Cause Mortality and Cancer Mortality (2014) Rosenquist KJ, Massaro JM, Pedley A, Long MT, Kreger BE, Vasan RS, Murabito JM, Hoffmann U, Fox CS. Journal of Clinical Endocrinology & Metabolism 2014 Sep 16:jc20134296. [Epub ahead of print]

Bone marrow from blotchy mice is nonessential to regulate blood copper and aortic pathologies in LDLR deficient mice during chronic angiotensin II infusion (2014) Harris D, Liang Y, Chen C, Li S, Patel O, Qin Z Annals of Vascular Surgery
 
Therapy Indications
 

Circulating acute phase proteins in relation to extent and composition of coronary atherosclerosis and cardiovascular outcome: results from the ATHEROREMO-IVUS study (2014) Battes LC, Akkerhuis KM, Cheng JM, Garcia-Garcia HM, Oemrawsingh RM, de Boer SPM, Reger E, van Geuns R-J, Serruys PW, Boersma E, Kardys I International Journal of Cardiology
 
Therapy Indications
 

Cardiac mMCP-4+ mast cell expansion and elevation of IL-6, and CCR1/3 and CXCR2 signaling chemokines in an adjuvant-free mouse model of tree nut allergy. (2014) Gonipeta B, Para R, He Y, Srkalovic I, Ortiz T, Kim E, Parvataneni S, Gangur V. Immunobiology. 2014 Dec 2. pii: S0171-2985(14)00237-X. doi: 10.1016/j.imbio.2014.11.012. [Epub ahead of print]

Obesity superimposed on aging magnifies inflammation and delays the resolving response following myocardial infarction. (2014) Lopez EF, Kabarowski J, Ingle KA, Kain V, Barnes S, Crossman DK, Lindsey ML, Halade GV. Am J Physiol Heart Circ Physiol. 2014 Dec 5:ajpheart.00604.2014. doi: 10.1152/ajpheart.00604.2014. [Epub ahead of print]
 
Therapy Indications
 

Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction. (2014) B?r C, de Jesus BB, Serrano R, Tejera A, Ayuso E, Jimenez V, Formentini I, Bobadilla M, Mizrahi J, de Martino A, Gomez G, Pisano D, Mulero F, Wollert KC, Bosch F, Blasco MA. Nat Commun. 2014 Dec 18;5:5863. doi: 10.1038/ncomms6863.
 
Therapy Indications
 

Cardiac aging is initiated by matrix metalloproteinase-9-mediated endothelial dysfunction. (2014) Yabluchanskiy A, Ma Y, Chiao YA, Lopez EF, Voorhees AP, Toba H, Hall ME, Han HC, Lindsey ML, Jin YF. Am J Physiol Heart Circ Physiol. 2014 May 15;306(10):H1398-407. doi: 10.1152/ajpheart.00090.2014. Epub 2014 Mar 21.
 
Therapy Indications
 

The Application of Multiple Reaction Monitoring to Assess Apoa-I Methionine Oxidations in Diabetes and Cardiovascular Disease (2014) Yassine HN, Jackson AM, Reaven PD, Nedelkov D, Nelson RW, Lau SS, Borchers CH Translational Proteomics

Circulating Cytokines in Relation to the Extent and Composition of Coronary Atherosclerosis: Results from the Atheroremo-Ivus Study (2014) Battes LC, Cheng JM, Oemrawsingh RM, Boersma E, Garcia-Garcia HM, De Boer SPM, Buljubasic N, Mieghem NaV, Regar E, Geuns R-JV, Serruys PW, Akkerhuis KM, Kardys I Atherosclerosis
 
Therapy Indications
 

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2013

Monitoring biomarkers after pediatric heart surgery: a new paradigm on the horizon (2013) Aqirbasli M, Undar A. Artif Organs. 2013 Jan;37(1):10-5.
 
Therapy Indications
 

Susceptibility of adult and senescent Brown Norway rats to repeated ozone exposure: an assessment of behavior, serum biochemistry and cardiopulmonary function (2013) Gordon CJ, Jarema KA, Lehmann JR, Ledbetter AD, Schladweiler MC, Schmid JE, Ward WO, Kodavanti UP, Nyska A, Macphail RC. Inhal Toxicol. 2013 Feb;25(3):141-59.
 
Therapy Indications
 

Clinical significance of plasma VEGF value in ischemic stroke - research for biomarkers in ischemic stroke (REBIOS) study (2013) Matsuo R, Ago T, Kamouchi M, Kuroda J, Kuwashiro T, Hata J, Sugimori H, Fukuda K, Gotoh S, Makihara N, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T BMC Neurol. 2013 Apr 8;13(1):32
 
Therapy Indications
 

Cytokines Associated with Increased Erythropoiesis in Sprague-Dawley Rats Administered a Novel Hyperglycosylated Analog of Recombinant Human Erythropoietin (2013) Andrews DA, Hamadeh HK, He YD, Boren BM, Turk JR, Boyce RW, Mytych DT, Barger TE, Salimi-Moosavi H, Sloey B, Elliott S, McElroy P, Sinclair AM, Shimamoto G, Pyrah IT, Lightfoot-Dunn RM Toxicol Pathol. 2013 May 14. [Epub ahead of print]
 
 

Dose-related Differences in the Pharmacodynamic and Toxicologic Response to a Novel Hyperglycosylated Analog of Recombinant Human Erythropoietin in Sprague-Dawley Rats with Similarly High Hematocrit (2013) Andrews DA, Boren BM, Turk JR, Boyce RW, He YD, Hamadeh HK, Mytych DT, Barger TE, Salimi-Moosavi H, Sloey B, Elliott S, McElroy P, Sinclair AM, Shimamoto G, Pyrah IT, Lightfoot-Dunn RM Toxicol Pathol. 2013 May 14. [Epub ahead of print]
 
Therapy Indications
 

Targeting oxidized LDL improves insulin sensitivity and immune cell function in obese Rhesus macaques (2013) Li S,Kievit P, Robertson A-K, Kolumam G. Li X, von Wachenfeldt K, Valfridsson C, Bullens S, Messaoudi I, Bader L, Cowan KJ, Kamath A, van Bruggen N, Bunting S, Frend?us B, Grove KL Molecular Metabolism, Available online 11 June 2013
 
Therapy Indications
 

Modulation of cardiometabolic pathways in skin and serum from patients with psoriasis (2013) Mehta NN, Li K, Szapary P, Krueger J, Brodmerkel C J Transl Med. 2013 Aug 22;11(1):194.

Circulating Porphyromonas gingivalis lipopolysaccharide resets cardiac homeostasis in mice through a matrix metalloproteinase-9-dependent mechanism (2013) DeLeon-Pennell KY,de Castro Br?s LE, Lindsey ML Physiological Reports Volume 1, Issue 5, October 2013
 
Therapy Indications
 

Reduced Bdnf Attenuates Inflammation and Angiogenesis to Improve Survival and Cardiac Function Following Myocardial Infarction in Mice (2013) Halade GV, Ma Y, Ramirez TA, Zhang J, Dai Q, Hensler JG, Lopez EF, Ghasemi O, Jin Y-F, Lindsey ML American Journal of Physiology - Heart and Circulatory Physiology
 
Therapy Indications
 

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2012

The kinetics of cardiopulmonary bypass: a dual-platform proteomics study of plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass (2012) Umstead TM, Lu CJ, Freeman WM, Myers JL, Clark JB, Thomas NJ, Icitovic N, Chinchilli VM, Undar A, Phelps DS Artif Organs. 2012 Jan;36(1):E1-E20.
 
Therapy Indications
 

Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule 1 (KIM-1) as Predictors of Incident CKD Stage 3: The Atherosclerosis Risk in Communities (ARIC) Study (2012) Bhavsar NA, K?ttgen A, Coresh J, Astor BC Am J Kidney Dis. 2012 Apr 27. [Epub ahead of print]
 
Therapy Indications
 

First-Trimester Prediction of Preeclampsia in Nulliparous Women at Low Risk (2012) Myatt L, Clifton RG, Roberts JM, Spong CY, Hauth JC, Varner MW, Thorp JM Jr, Mercer BM, Peaceman AM, Ramin SM, Carpenter MW, Iams JD, Sciscione A, Harper M, Tolosa JE, Saade G, Sorokin Y, Anderson GD Obstet Gynecol. 2012 Jun;119(6):1234-1242
 
Therapy Indications
 

Cardiovascular risk factors, cortisol, and amyloid-? deposition in Alzheimer's Disease Neuroimaging Initiative (2012) Toledo JB, Toledo E, Weiner MW, Jack CR Jr, Jagust W, Lee VM, Shaw LM, Trojanowski JQ; Alzheimer's Disease Neuroimaging Initiative Alzheimers Dement. 2012 Nov;8(6):483-9
 
 

Aging Exacerbates Obesity-Induced Oxidative Stress and Inflammation in Perivascular Adipose Tissue in Mice: A Paracrine Mechanism Contributing to Vascular Redox Dysregulation and Inflammation (2012) Bailey-Downs LC, Tucsek Z, Toth P, Sosnowska D, Gautam T, Sonntag WE, Csiszar A, Ungvari Z J Gerontol A Biol Sci Med Sci. 2012 Dec 3. [Epub ahead of print]

Plasma Lipid Profiling across Species for the Identification of Optimal Animal Models of Human Dyslipidemia (2012) Yin W, Carballo-Jane E, Mclaren DG, Mendoza VH, Gagen K, Geoghagen NS, Mcnamara LA, Gorski JN, Eiermann GJ, Petrov A, Wolff M, Tong X, Wilsie LC, Akiyama TE, Chen J, Thankappan A, Xue J, Ping X, Andrews G, Wickham LA, Gai CL, Trinh T, Kulick AA, Donnelly MJ, Voronin GO, Rosa R, Cumiskey A-M, Bekkari K, Mitnaul LJ, Puig O, Chen F, Raubertas R, Wong PH, Hansen BC, Koblan KS, Roddy TP, Hubbard BK, Strack AM Journal of Lipid Research

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2011

Homozygous mutation in SAMHD1 gene causes cerebral vasculopathy and early onset stroke (2011) Xin B, Jones S, Puffenberger EG, Hinze C, Bright A, Tan H, Zhou A, Wu G, Vargus-Adams J, Agamanolis D, Wang H Proc Natl Acad Sci U S A. 2011 Mar 14. [Epub ahead of print]
 
Therapy Indications
 

Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice (2011) Erdely A, Hulderman T, Salmen-Muniz R, Liston A, Zeidler-Erdely PC, Chen BT, Stone S, Frazer DG, Antonini JM, Simeonova PP Toxicol Lett. 2011 Jul 4;204(1):12-6.
 
Therapy Indications
 

Combining experimental and mathematical modeling to reveal mechanisms of macrophage-dependent left ventricular remodeling (2011) Jin YF, Han HC, Berger J, Dai Q, Lindsey ML BMC Syst Biol. 2011 May 5;5(1):60. [Epub ahead of print]
 
Therapy Indications
 

TGF-?2 treatment enhances cytoprotective factors released from embryonic stem cells and inhibits apoptosis in infarcted myocardium (2011) Singla DK, Singla RD, Lamm S, Glass C Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1442-50
 
Therapy Indications
 

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells (2011) Facciabene A, Peng X, Hagemann IS, Balint K, Barchetti A, Wang LP, Gimotty PA, Gilks CB, Lal P, Zhang L, Coukos G Nature. 2011 Jul 13;475(7355):226-30
 
Therapy Indications
 

Multi-analyte profiling reveals matrix metalloproteinase-9 and monocyte chemotactic protein-1 as plasma biomarkers of cardiac aging (2011) Chiao YA, Dai Q, Zhang J, Lin J, Lopez EF, Ahuja SS, Chou YM, Lindsey ML, Jin YF Circ Cardiovasc Genet. 2011 Aug 1;4(4):455-62
 
Therapy Indications
 

Growth Hormone and IGF-1 Deficiency Exacerbate High-Fat Diet-Induced Endothelial Impairment in Obese Lewis Dwarf Rats: Implications for Vascular Aging (2011) Bailey-Downs LC, Sosnowska D, Toth P, Mitschelen M, Gautam T, Henthorn JC, Ballabh P, Koller A, Farley JA, Sonntag WE, Csiszar A, Ungvari Z J Gerontol A Biol Sci Med Sci. 2011 Nov 10. [Epub ahead of print]

Effects of DPP-4 Inhibitors on the Heart in a Rat Model of Uremic Cardiomyopathy (2011) Chaykovska L, von Websky K, Rahnenf?hrer J, Alter M, Heiden S, Fuchs H, Runge F, Klein T, Hocher B PLoS ONE 6(11): e27861
 
Therapy Indications
 

Matrix Metalloproteinase-28 Deletion Amplifies Inflammatory and Extracellular Matrix Responses to Cardiac Aging (2011) Ma Y, Chiao YA, Zhang J, Manicone AM, Jin YF, Lindsey ML Microsc Microanal. 2011 Dec 8:1-10. [Epub ahead of print]

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2010

Inflammatory and Hemostatic Response to Cardiopulmonary Bypass in Pediatric Population: Feasibility of Seriological Testing of Multiple Biomarkers (2010) Agirbasli M, Nguyen ML, Win K, Kunselman AR, Clark JB, Myers JL, Undar A Artif Organs. 34: 987-95.

Cardiovascular and inflammatory effects of intratracheally instilled ambient dust from Augsburg, Germany, in spontaneously hypertensive rats (SHRs) (2010) Upadhyay S, Ganguly K, Stoeger T, Semmler-Bhenke M, Takenaka S, Kreyling WG, Pitz M, Reitmeir P, Peters A, Eickelberg O, Wichmann HE, Schulz H Part Fibre Toxicol. 7: 27.

Bevacizumab therapy normalizes the pathological intraocular environment beyond neutralizing VEGF (2010) Sharma RK, Rogojina AT, Chalam KV Mol Vi. 16: 2175-2184.
 
Therapy Indications
 

A Semi-Targeted Plasma Proteomics Discovery Workflow Utilizing Two-Stage Protein Depletion and Off-Line LC-MALDI MS/MS (2010) Juhasz P, Lynch M, Sethuraman M, Campbell J, Hines W, Paniagua M, Song L, Kulkarni M, Adourian A, Guo Y, Li X, Martin S, Gordon N J Proteome Res. 2010 Oct 11. [Epub ahead of print]
 
Therapy Indications
Miscellaneous
Cardiovascular
 

Limited Systemic Sclerosis Patients with Pulmonary Arterial Hypertension Show Biomarkers of Inflammation and Vascular Injury (2010) Pendergrass SA, Hayes E, Farina G, Lemaire R, Farber HW, Whitfield ML, Lafyatis R. PLoS ONE 5: e12106.

Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis (2010) Woo JM, Lin Z, Navab M, Van Dyck C, Trejo-Lopez Y, Woo KM, Li H, Castellani LW, Wang X, Iikuni N, Rullo OJ, Wu H, La Cava A, Fogelman AM, Lusis AJ, Tsao BP Arthritis Res Ther 12: R93.

Cholesterol in human atherosclerotic plaque is a marker for underlying disease state and plaque vulnerability (2010) Chen Z, Ichetovkin M, Kurtz M, Zycband E, Kawka D, Woods J, He X, Plump AS, Hailman E Lipids Health Dis 11: 61.
 
Therapy Indications
 

Human cytokine response to Texas crotaline envenomation before and after antivenom administration. (2010) Crocker P, Zad O, Milling T, Maxson T, King B, Whorton E Am J Emerg Med. 28: 871-9.
 
 

A Dual-Platform Proteomics Study of Plasma Biomarkers in Pediatric Patients Undergoing Cardiopulmonary Bypass. (2010) Umstead TM, Lu CJ, Freeman WM, Myers JL, Clark JB, Thomas NJ, Chinchilli VM, Vrana KE, Undar A, Phelps DS Pediatr Res 67: 641-9.

Hypercoagulability, platelet function, inflammation and coronary artery disease acuity: Results of the Thrombotic RIsk Progression (TRIP) Study. (2010) Tantry US, Bliden KP, Suarez TA, Kreutz RP, Dichiara J, Gurbel PA Platelets 21: 360-7.

Systemic levels of G-CSF and interleukin-6 determine the angiogenic potential of bone marrow resident monocytes. (2010) Gregory AD, Capoccia BJ, Woloszynek JR, Link DC J Leukoc Biol 88: 123-31.
 
Therapy Indications
 

Feasibility of FDG imaging of the coronary arteries: comparison between acute coronary syndrome and stable angina. (2010) Rogers IS, Nasir K, Figueroa AL, Cury RC, Hoffmann U, Vermylen DA, Brady TJ, Tawakol A JACC Cardiovasc Imaging 3: 388-397.
 
Therapy Indications
 

Comparative efficacy and safety of aliskiren and irbesartan in patients with hypertension and metabolic syndrome. (2010) Krone W, Hanefeld M, Meyer HF, Jung T, Bartlett M, Yeh CM, Rajman I, Prescott MF, Dole WP J Hum Hypertens [Epub ahead of print]

A phase 2 pilot trial of low-dose, continuous infusion, or "metronomic" paclitaxel and oral celecoxib in patients with metastatic melanoma. (2010) Bhatt RS, Merchan J, Parker R, Wu HK, Zhang L, Seery V, Heymach JV, Atkins MB, McDermott D, Sukhatme VP Cancer 116: 1751-1756.
 
Therapy Indications
 

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2009

Chronic Treatment with Clenbuterol Modulates Endothelial Progenitor Cells and Circulating Factors in a Murine Model of Cardiomyopathy. (2009) Rider JE, Polster SP, Lee S, Charles NJ, Adhikari N, Mariash A, Tadros G, Stangland J, Smolenski RT, Terracciano CM, Barton PJR, Birks EJ, Yacoub MH, Miller LW, Hall JL Journal of Cardiovascular Translational Research 2: 182?190.
 
Therapy Indications
 

Heart Failure Therapy Mediated by the Trophic Activities of Bone Marrow Mesenchymal Stem Cells: A Non-invasive Therapeutic Regimen. (2009) Shabbir A, Zisa D, Suzuki G, Lee T Am J Physiol Heart Circ Physiol 296: H1888-H1897.
 
Therapy Indications
 

Atorvastatin Restores Endothelial Function in Offspring of Protein-Restricted Rats in a Cholesterol-Independent Manner. (2009) Torrens C, Kelsall CJ, Hopkins LA, Anthony FW, Curzen NP, Hanson MA Hypertension 53: 661-667.
 
Therapy Indications
 

Myocardial Oxidative Stress, Osteogenic Phenotype, and Energy Metabolism are Differentially Involved in the Initiation and Early Progression of d-sarcoglycan-null Cardiomyopathy. (2009) Missihoun C, Zisa D, Shabbir A, Lin H, Lee T Mol Cell Biochem 321: 45-52.
 
Therapy Indications
 

The Link Between Heightened Thrombogenicity and Inflammation: Pre-Procedure Characterization of the Patient at High Risk for Recurrent Events After Stenting. (2009) Gurbel PA, Bliden KP, Kreutz RP, Dichiara J, Antonino MJ, Tantry US Platelets 20: 97-104.
 
Therapy Indications
 

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2008

Circulating Markers Reflect Both Anti- and Pro-Atherogenic Drug Effects in ApoE-Deficient Mice. (2008) Liao B, McCall E, Cox K, Lee CW, Huang S, Higgs RE, Chio LC, Zhen E, Hale JE, Jackson NK, Rutherford PG, Huang XD, Gifford-Moore D, Hui K, Duffin K, Gould KE, Rekhter M Biomark Insights 3: 147-157.
 
Therapy Indications
 

Biomarker analysis by fluorokine multianalyte profiling distinguishes patients requiring intervention from patients with long-term quiescent coronary artery disease: a potential approach to identify atherosclerotic disease progression. (2008) Gurbel PA, Kreutz RP, Bliden KP, DiChiara J, Tantry US Am Heart J 155: 56-61.
 
Therapy Indications
 

Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE-/- mice. (2008) Cuaz-P?rolin C, Billiet L, Baug? E, Copin C, Scott-Algara D, Genze F, B?chele B, Syrovets T, Simmet T, Rouis M Arterioscler Thromb Vasc Biol 28: 272-277.

Endothelial activation markers in anemic non-dialysis chronic kidney disease patients. (2008) Patel TV, Mittal BV, Keithi-Reddy SR, Duffield JS, Singh AK Nephron Clin Pract 110: c244-250.

Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: therapeutic strategies (2008) Adibhatla RM, Hatcher JF CNS Neurol Disord Drug Targets. 2008 Jun;7(3):243-53
 
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2007

Phase I study of eptifibatide in patients with sickle cell anaemia. (2007) Lee SP, Ataga KI, Zayed M, Manganello JM, Orringer EP, Phillips DR, Parise LV Br J Haematol 139: 612-620.
 
Therapy Indications
 

Modeled gravitational unloading induced downregulation of endothelin-1 in human endothelial cells. (2007) Infanger M, Ulbrich C, Baatout S, Wehland M, Kreutz R, Bauer J, Grosse J, Vadrucci S, Cogoli A, Derradji H, Neefs M, K?sters S, Spain M, Paul M, Grimm D J Cell Biochem 101: 1439-1455.
 
Therapy Indications
 

Multi-Analyte Profiling of Post-Myocardial Infarction Plasma Samples. (2007) Escobar GP and Lindsey ML FASEB J. 21: 746.11.
 
Therapy Indications
 

Femoral artery neointimal hyperplasia is reduced after wire injury in Ref-1+/- mice. (2007) Basi DL, Adhikari N, Mariash A, Li Q, Kao E, Mullegama SV, Hall JL Am J Physiol Heart Circ Physiol 292: H516-H521.
 
Therapy Indications